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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
24.55
Human Site:
Y753
Identified Species:
49.09
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
Y753
E
R
D
I
N
S
L
Y
D
V
S
R
M
Y
V
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
Y753
E
R
D
I
N
S
L
Y
D
V
S
R
M
Y
V
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
Y753
E
R
D
I
N
S
L
Y
D
V
S
R
M
Y
V
Dog
Lupus familis
XP_546812
1252
146274
Y753
E
R
D
I
N
S
L
Y
D
V
S
R
M
Y
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
Y753
E
R
D
I
N
S
L
Y
D
V
S
R
M
Y
V
Rat
Rattus norvegicus
P24135
1265
147716
Y753
E
R
D
I
N
S
L
Y
D
V
S
R
M
Y
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
N492
Y
V
D
P
S
E
I
N
P
S
T
P
Q
R
T
Chicken
Gallus gallus
Q2VRL0
637
72514
R138
L
S
F
E
G
F
I
R
Y
M
S
S
E
D
C
Frog
Xenopus laevis
Q32NH8
758
87399
K259
Y
E
P
S
D
T
A
K
K
L
H
A
M
S
I
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
L285
N
D
W
A
Q
K
N
L
F
M
T
Q
N
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
K635
I
S
F
R
A
E
N
K
I
K
H
C
R
I
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
Y441
K
V
T
V
K
A
L
Y
D
Y
K
A
Q
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
6.6
6.6
0
N.A.
N.A.
0
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
20
33.3
20
N.A.
N.A.
0
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
9
9
9
0
0
0
0
17
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% C
% Asp:
0
9
59
0
9
0
0
0
59
0
0
0
0
9
0
% D
% Glu:
50
9
0
9
0
17
0
0
0
0
0
0
9
0
9
% E
% Phe:
0
0
17
0
0
9
0
0
9
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% H
% Ile:
9
0
0
50
0
0
17
0
9
0
0
0
0
9
9
% I
% Lys:
9
0
0
0
9
9
0
17
9
9
9
0
0
0
9
% K
% Leu:
9
0
0
0
0
0
59
9
0
9
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
17
0
0
59
0
0
% M
% Asn:
9
0
0
0
50
0
17
9
0
0
0
0
9
0
0
% N
% Pro:
0
0
9
9
0
0
0
0
9
0
0
9
0
0
0
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
0
9
17
0
0
% Q
% Arg:
0
50
0
9
0
0
0
9
0
0
0
50
9
17
0
% R
% Ser:
0
17
0
9
9
50
0
0
0
9
59
9
0
9
0
% S
% Thr:
0
0
9
0
0
9
0
0
0
0
17
0
0
0
9
% T
% Val:
0
17
0
9
0
0
0
0
0
50
0
0
0
0
50
% V
% Trp:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
17
0
0
0
0
0
0
59
9
9
0
0
0
50
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _